Medications Compounded for Oncology Patients

Pharmacy Solutions compounds a variety of medications for oncology patients when prescribed by a qualified healthcare provider. Common examples include mebendazole, ivermectin, metformin, atorvastatin and doxycycline. These medications are FDA-approved for their original indications but have also appeared in published oncology research. Any use outside the original approved indication is considered off-label, meaning the prescribing provider is relying on their clinical judgment and review of available research. Pharmacy Solutions does not recommend or prescribe any medication. When a healthcare provider issues a prescription, the pharmacy can prepare these medications in customized strengths or formulations according to the provider’s specifications. Some providers prescribe combinations of these medications as part of individualized approaches such as the COC Protocol developed by Care Oncology Clinic. Pharmacy Solutions can compound medications prescribed as part of such protocols when a provider issues a prescription. All compounding is performed under strict quality standards. The pharmacy holds PCAB accreditation in both sterile and non-sterile compounding, is USP <800> compliant for the handling of hazardous drugs, sources all ingredients from FDA-registered facilities and tests all finished products through an independent third-party laboratory. If you are interested in exploring whether any of these medications might be appropriate for your situation, speak with your healthcare provider.

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Going through treatment was hard enough without having to worry about getting my medications right. The pharmacy worked with my doctor to make sure I had exactly what I needed, when I needed it.

Louise C.

Age 53

Going through treatment was difficult enough without having to worry about my medications. The pharmacy worked with my doctor to make sure everything was prepared exactly the way I needed it, and that gave me one less thing to worry about.

Patricia W.

Age 61

When you’re navigating something this serious, you need a team that actually talks to each other. Knowing my pharmacist and my doctor were on the same page made everything feel a little less overwhelming.

Thomas R.

Age 59

What medications does Pharmacy Solutions compound for oncology patients?

Pharmacy Solutions compounds a variety of medications for oncology patients when prescribed by a healthcare provider. Common examples include mebendazole, ivermectin, metformin, atorvastatin and doxycycline. The pharmacy prepares medications according to the prescriber’s specifications and does not recommend or promote any specific medication.

Are these medications FDA-approved for cancer?

The medications described on this page are FDA-approved for their original indications but have not been approved by the FDA for any oncology indication. Any use in oncology is considered off-label, meaning the prescribing provider is relying on their clinical judgment and review of available research rather than an FDA-approved indication.

What is the COC Protocol?

The COC Protocol is an approach developed by Care Oncology Clinic that involves the use of metformin, atorvastatin, doxycycline and mebendazole in combination. Pharmacy Solutions can compound medications prescribed as part of this protocol when a healthcare provider issues a prescription. The pharmacy does not recommend or promote the protocol itself.

Do I need a prescription to get these medications?

Yes. Pharmacy Solutions compounds medications only when a licensed healthcare provider has issued a valid prescription. The pharmacy cannot dispense prescription medications without a prescriber’s order.

Can Pharmacy Solutions help me find a provider?

If you need assistance connecting with a healthcare provider who is familiar with compounded medications or repurposed drug protocols, click Ask a Pharmacist or contact Pharmacy Solutions directly. The pharmacy can provide information about the process and may be able to assist with provider connections.

What quality standards does Pharmacy Solutions follow?

Pharmacy Solutions is PCAB accredited in both sterile and non-sterile compounding, is USP <800> compliant for the handling of hazardous drugs, sources all ingredients from FDA-registered facilities and tests all finished products through an independent third-party laboratory.

How is compounding different from commercial medications?

Compounding allows a pharmacy to prepare medications in customized strengths, formulations or dosage forms based on a prescriber’s specifications. This may be appropriate when a patient requires a dosage not commercially available, needs a medication without certain inactive ingredients, or requires an alternative dosage form such as a liquid or topical preparation.

References

[1] U.S. Food and Drug Administration. Understanding Unapproved Use of Approved Drugs “Off Label.” FDA.gov. https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label
[2] Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole as anti-parasitic and anti-cancer agents: an update. Korean Journal of Parasitology. 2021;59(3):189-225.
[3] Guerini AE, Triggiani L, Maddalo M, et al. Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Cancers. 2019;11(9):1284.
[4] Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP. Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443.
[5] Mansoori S, Fryknäs M, Alvfors C, et al. A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer. Scientific Reports. 2021;11:8981.
[6] Crump A, Omura S. Ivermectin, ‘wonder drug’ from Japan: the human use perspective. Proceedings of the Japan Academy, Series B. 2011;87(2):13-28.
[7] Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug. American Journal of Cancer Research. 2018;8(2):317-331.
[8] Bailey CJ. Metformin: historical overview. Diabetologia. 2017;60(9):1566-1576.
[9] Yin M, Zhou J, Gorak EJ, Quddus F. Metformin Is Associated with Survival Benefit in Cancer Patients with Concurrent Type 2 Diabetes: A Systematic Review and Meta-Analysis. The Oncologist. 2013;18(12):1248-1255.
[10] Sirtori CR. The pharmacology of statins. Pharmacological Research. 2014;88:3-11.
[11] Singh S, Singh PP. Statin a day keeps cancer at bay. World Journal of Clinical Oncology. 2013;4(2):43-46.
[12] Cunha BA, Sibley CM, Ristuccia AM. Doxycycline. Therapeutic Drug Monitoring. 1982;4(2):115-135.
[13] Zhang L, Xu L, Zhang F, Vlashi E. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017;16(8):737-745.
[14] Care Oncology Clinic. The COC Protocol. https://careoncologyclinic.com
[15] Pharmacy Compounding Accreditation Board (PCAB). Accreditation Commission for Health Care (ACHC). https://www.achc.org/pcab/

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